Journal
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
Volume 25, Issue 1, Pages 7-12Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNP.0b013e318163ccd5
Keywords
magnetoencephalography; cognition; naming
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Funding
- NINDS NIH HHS [P01 NS046588, P01 NS046588-05, P51-NS046588] Funding Source: Medline
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Eight right-handed subjects were asked to silently generate a verb to a visual stimulus while the magnetic flux normal to the scalp surface was recorded with a whole-head neuromagnetometer. The spatiotemporal patterns of activation in lateral occipital, inferior parietal, superior temporal, basal temporal, and inferior frontal cortices were estimated using minimum estimation, a distributed source analysis methodology. Although there was significant variability among subjects, averaged data indicated that latencies of peak activation in these regions of interest progressed from posterior to anterior. Peak latencies were earliest in lateral occipital cortex and latest in pars opercularis and pars triangularis in the inferior frontal gyrus. Lateralization of activation was strongest in pars opercularis, which is part of classical Broca's area, with activation being stronger in this area within the left hemisphere in every subject. Results provide support for the use of magnetoencephalography in conjunction with NINE analysis for the purpose of lateralizing and localizing language-specific activation in frontal areas as well as the study of the spatiotemporal parameters of brain activation associated with cognitive function.
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