Journal
JOURNAL OF CLINICAL NEUROLOGY
Volume 8, Issue 2, Pages 130-138Publisher
KOREAN NEUROLOGICAL ASSOC
DOI: 10.3988/jcn.2012.8.2.130
Keywords
primary insomnia; hippocampus; volumetry; memory; sleep
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Funding
- Brain Research Center of the 21st Century Frontier Research Program [2010K000817]
- Ministry of Education, Science, and Technology
- Korean Health Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea [A110097]
- Global Frontier R&D Program on &LANGBRAC
- Human-centered Interaction for Coexistence&RANGBRAC
- National Research Foundation of Korea
- Korean Government (MEST) [NRF-M1AXA 003-2011-0031688]
- Korea Health Promotion Institute [A110097, A110097120001] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Background and Purpose Differences in hippocampal volume (HV) were compared between chronic primary insomniacs (PIs) and good sleepers (GSs), and the relationship between HV and memory function in PIs was investigated to clarify the effect of chronic sleep deprivation on brain structure and cognition. Methods Twenty PIs (mean age, 50 years; 18 females) and 20 age-, gender-, and education-matched GSs were enrolled. Brain magnetic resonance imaging (MRI) was performed on a 1.5-T MRI scanner. Left and right HV and intracranial volume (ICV) were measured manually. Nighttime polysomnography and neuropsychological testing were also applied to all subjects. Group differences in HV were analyzed and the relationships between HV and sleep questionnaire data, nighttime polysomnography, and neuropsychological findings were evaluated. Results Compared to GSs, PIs exhibited significantly increased sleep latency and arousal index and a decreased percentage of REM sleep in nighttime polysomnography, as well as impaired verbal and visual memory, and frontal lobe function. Absolute HV and ICV did not differ significantly between PIs and GSs. In the PIs, right and left HVs were negatively correlated with the duration of insomnia and the arousal index, and positively correlated with the recognition of visual memory. In addition, free recall in verbal memory was positively correlated with left HV in PIs. Conclusions These findings suggest that chronic sleep deprivation impairs memory and frontal lobe function, and that a long duration of insomnia and poor sleep quality contribute to a bilateral reduction in HV. J Clin Neurol 2012;8:130-138
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