4.7 Article

The Molecular Bacterial Load Assay Replaces Solid Culture for Measuring Early Bactericidal Response to Antituberculosis Treatment

Journal

JOURNAL OF CLINICAL MICROBIOLOGY
Volume 52, Issue 8, Pages 3064-3067

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.01128-14

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Funding

  1. European Metrology Research Programme (EMRP) EURAMET [HLT-08 INFECT-MET]
  2. EMRP within EURAMET
  3. EMRP within European Union
  4. European and Developing Countries Clinical Trials Partnership [IP.2007.32011.013]
  5. German Ministry for Education and Research [01KA0901]
  6. MRC [MC_U122888469, G0601466] Funding Source: UKRI
  7. Medical Research Council [MC_U122888469, G0601466] Funding Source: researchfish

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We evaluated the use of the molecular bacterial load (MBL) assay, for measuring viable Mycobacterium tuberculosis in sputum, in comparison with solid agar and liquid culture. The MBL assay provides early information on the rate of decline in bacterial load and has technical advantages over culture in either form.

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