4.7 Article

Breakthrough Invasive Candida glabrata in Patients on Micafungin: a Novel FKS Gene Conversion Correlated with Sequential Elevation of MIC

Journal

JOURNAL OF CLINICAL MICROBIOLOGY
Volume 52, Issue 7, Pages 2709-2712

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AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.03593-13

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Funding

  1. Health Science Research Grant for Research on Emerging and Re-emerging Infectious Diseases [H24-Shinkou-Wakate-015]

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Candida glabrata strains sequentially isolated from blood developed resistance to micafungin (MICs from <0.015 to 4 mu g/ml). A novel mutation identified in micafungin-resistant strains at bp 262 of FKS2 (containing a deletion of F659 [F659del]) was inserted into the homologous region in FKS1.

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