Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 50, Issue 7, Pages 2441-2443Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.01002-12
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Funding
- Ministry of Health of the Czech Republic [NT11032-6/2010]
- Ministry of Education of the Czech Republic [MSM0021620819]
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Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) is a potentially useful tool for the detection of antimicrobial resistance, especially that conferred by beta-lactamases. Here we describe a modification of a previously reported MALDI-TOF MS meropenem hydrolysis assay. The modified method was validated on 108 carbapenemase-producing members of the Enterobacteriaceae, two NDM-1-producing Acinetobacter baumannii isolates, and 35 carbapenem-resistant enterobacteria producing no carbapenemase. The detection of carbapenemases by MALDI-TOF MS seems to be a powerful, quick, and cost-effective method for microbiological laboratories.
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