4.7 Article

A Reliable and Reproducible Experimental Challenge Model for Peste des Petits Ruminants Virus

Journal

JOURNAL OF CLINICAL MICROBIOLOGY
Volume 50, Issue 11, Pages 3738-3740

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.01785-12

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Funding

  1. Biotechnology and Biological Sciences Research Council [BB/H009485/1] Funding Source: Medline
  2. BBSRC [BB/H009485/1] Funding Source: UKRI
  3. Biotechnology and Biological Sciences Research Council [BB/H009485/1] Funding Source: researchfish

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Experimental challenge protocols that consistently reproduce clinical signs of peste des petits ruminants in Alpine goats infected with a tissue culture-passaged peste des petits ruminants virus are described. The protocols can be used to carry out quality-controlled vaccine efficacy and pathogenesis studies under experimental conditions.

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