Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 50, Issue 7, Pages 2509-2512Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.00791-12
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Funding
- REIPI (Red Espanola de Investigacion en Patologia Infecciosa) [MPY 1022/07_1]
- Instituto de Salud Carlos III
- European Development Regional Fund A Way to Achieve Europe
- Spanish Network for Research in Infectious Diseases [REIPI RD06/0008]
- National Institute of Health Research clinician scientist award
- Astellas
- Gilead
- Merck Sharp and Dohme (MSD)
- Pfizer
- Merck
- Vectura
- F2G
- Astellas Pharma
- Gilead Sciences
- MSD
- Schering-Plough
- Soria Melguizo S.A.
- European Union
- Spanish Agency for International Cooperation
- Spanish Ministry of Culture and Education
- Spanish Health Research Fund
- Ramon Areces Foundation
- Mutua Madrilena Foundation
- bioMerieux
- Ferrer International
- ALBAN program
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Ninety-six strains of Candida, including 29 resistant and 67 susceptible isolates with mutations in the FKS1 and FKS2 genes were tested by the European Committee on Antibiotic Susceptibility Testing EDef7.1 and 7.2 methodologies to determine the impact on the MIC when water was replaced with dimethyl sulfoxide (DMSO) as the solvent for caspofungin and micafungin. The MICs were significantly lower and the MIC ranges were narrower when DMSO was used as the solvent. The use of DMSO may help to better discriminate between susceptible and resistant populations.
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