Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 50, Issue 9, Pages 3073-3076Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.00992-12
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We present the evolution of testing algorithms at our institution in which the C. Diff Quik Chek Complete immunochromatographic cartridge assay determines the presence of both glutamate dehydrogenase and Clostridium difficile toxins A and B as a primary screen for C. difficile infection and indeterminate results (glutamate dehydrogenase positive, toxin A and B negative) are confirmed by the GeneXpert C. difficile PCR assay. This two-step algorithm is a cost-effective method for highly sensitive detection of toxigenic C. difficile.
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