4.7 Article

Genetic Characterization of Multidrug-Resistant, Extended-Spectrum-β-Lactamase-Producing Vibrio cholerae O1 Outbreak Strains, Mpumalanga, South Africa, 2008

Journal

JOURNAL OF CLINICAL MICROBIOLOGY
Volume 49, Issue 8, Pages 2976-2979

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.00293-11

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Funding

  1. NHLS Research Trust (NHLSRT)
  2. GERMS-SA
  3. EDRU

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Thirty-one antimicrobial-resistant, extended-spectrum-beta-lactamase-producing strains of Vibrio cholerae O1 serotype Ogawa associated with an outbreak of cholera in South Africa (2008) were investigated. Ten selected cholera strains were PCR positive for the SXT element, harbored mutations in the quinolone resistance-determining regions of GyrA (Ser83-Ile) and ParC (Ser85-Leu), and produced TEM-63 beta-lactamase.

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