Evaluation of Disk Approximation and Single-Well Broth Tests for Detection of Inducible Clindamycin Resistance in Streptococcus pneumoniae

This study evaluated an agar disk diffusion D-zone test and an erythromycin-clindamycin (ERY + CLI) single-well broth test for inducible CLI resistance in Streptococcus pneumoniae. The standard CLSI disk approximation test and a single-well combination test incorporating 1 plus 0.5 mu g/ml ERY + CLI detected >96% of isolates containing the ermB determinant.