4.7 Article

Value of the Modified Hodge Test for Detection of Emerging Carbapenemases in Enterobacteriaceae

Journal

JOURNAL OF CLINICAL MICROBIOLOGY
Volume 50, Issue 2, Pages 477-479

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.05247-11

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Funding

  1. INSERM [U914]
  2. Ministere de l'Education Nationale et de la Recherche [UPRES-EA 3539]
  3. Universite Paris XI, Paris, France
  4. European Community [TEMPOtest-QC, HEALTH-2009-241742]

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The modified Hodge test has an excellent sensitivity for detecting enterobacterial isolates producing Ambler class A (KPC) and class D (OXA-48) carbapenemases. Its sensitivity is low for NDM-1 producers (50%) but is increased to 85.7% by adding ZnSO4 (100 mu g/ml) in the culture medium. However, this test has a low specificity and is time-consuming.

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