Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 49, Issue 11, Pages 3728-3732Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.05476-11
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Funding
- NIH [AI 19641]
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The widespread use of Haemophilus influenzae type b (Hib) conjugate vaccines has nearly eradicated invasive Hib disease where the vaccines are used. This success was accompanied by a shift in capsular serotypes of invasive H. influenzae disease, with nontypeable strains replacing type b strains as the most common blood-stream isolate, but there is no convincing evidence of a true increase in the incidence of non-serotype b invasive infections. H. influenzae causes predominantly mucosal infections. The introduction of vaccines for otitis media and global shifts in antimicrobial susceptibility emphasize the importance of continued surveillance of H. influenzae colonization and disease patterns.
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