Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 49, Issue 7, Pages 2688-2690Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.00659-11
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Funding
- Instituto de Salud Carlos III (Fondo de Investigaciones Sanitarias) [REF CA09/00054]
- Fondo de Investigaciones Sanitarias [S09/02205, IF01-3624, IF08-36173]
- Fondo de Investigaciones Sanitarias (Linea Instrumental Secuenciacion)
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Our study provides an alert regarding the transmission of rifampin-susceptible strains of Mycobacterium tuberculosis with a silent substitution in codon 514 of rpoB. Among 1,450 cases, we identified 12 isolates sharing this mutation and related restriction fragment length polymorphism (RFLP) types. The mutation impaired hybridization with the wild-type probes in three independent commercial assays, which could lead to misassignment of resistance.
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