4.7 Article

Mixed-Strain Mycobacterium tuberculosis Infections among Patients Dying in a Hospital in KwaZulu-Natal, South Africa

Journal

JOURNAL OF CLINICAL MICROBIOLOGY
Volume 49, Issue 1, Pages 385-388

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.01378-10

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Funding

  1. KwaZulu-Natal Department of Health
  2. Office of the Director, U.S. National Institutes of Health [DP2OD006663]
  3. Massachusetts General Hospital
  4. BMS Secure the Future
  5. Harvard University CFAR
  6. Ragon Institute
  7. Gary and Lauren Cohen
  8. Mark and Lisa Schwartz Foundation
  9. Witten Family Foundation
  10. Edendale Hospital
  11. OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP2OD006663] Funding Source: NIH RePORTER

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We performed spoligotyping and 24-locus mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) typing on M. tuberculosis culture-positive biopsy specimens collected from adults dying in a hospital in KwaZulu-Natal. Of 56 culture-positive samples genotyped, we detected mixed strains in five (9%) and clonal heterogeneity in an additional four (7%).

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