4.7 Article

Quantitative Analysis of a Urine-Based Assay for Detection of Lipoarabinomannan in Patients with Tuberculosis

Journal

JOURNAL OF CLINICAL MICROBIOLOGY
Volume 48, Issue 8, Pages 2972-2974

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.00363-10

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Funding

  1. Doris Duke Charitable Foundation
  2. United Kingdom Government through Department for International Development (DFID)
  3. NIH [AI48526, AI01637, T32AI007291-18]

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Urinary lipoarabinomannan (LAM) detection is a promising approach for rapid diagnosis of active tuberculosis (TB). In microbiologically confirmed TB patients, quantitative LAM detection results increased progressively with bacillary burden and immunosuppression. Patients with disseminated TB and/or advanced HIV are target populations for whom urine LAM detection may be particularly useful.

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