4.7 Article

Evaluation of Escherichia coli Cell Response to Antibiotic Treatment by Use of Raman Spectroscopy with Laser Tweezers

Journal

JOURNAL OF CLINICAL MICROBIOLOGY
Volume 48, Issue 11, Pages 4287-4290

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.01565-10

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Funding

  1. Children's Miracle Network
  2. Keaton-Raphael Memorial Fund
  3. National Science Foundation
  4. University of California, Davis [PHY 0120999]

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Laser tweezers Raman spectroscopy was used to detect the cellular response of Escherichia coli cells to penicillin G-streptomycin and cefazolin. Time-dependent intensity changes of several Raman peaks at 729, 1,245, and 1,660 cm(-1) enabled untreated cells and cells treated with the different antibiotic drugs to be distinguished.

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