Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 49, Issue 3, Pages 1137-1139Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.01831-10
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- Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III-FEDER, Spanish Network for the Research in Infectious Diseases (REIPI ) [RD06/0008]
- Institut d'Investigacio Biomedica de Bellvitge (IDIBELL)
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Sixty-four of 85 (75.3%) smear-negative respiratory (n = 78) and nonrespiratory (n = 7) samples with positive cultures of Mycobacterium tuberculosis complex (MTC) were detected by the GeneXpert system using the Xpert MTB/RIF assay (GX). In addition, GX found rpoB mutations in all six of the rifampin-resistant strains detected. The test was negative in 20 culture-negative and 20 nontuberculous culture-positive samples (100% specificity). GX offers high potential for the diagnosis of tuberculosis due to its capacity for direct detection of MTC, its rapidity, and its simplicity.
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