Journal
NEUROTOXICOLOGY
Volume 50, Issue -, Pages 108-115Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.neuro.2015.08.009
Keywords
Diesel exhaust particles; Maternal exposure; Learning; Memory; N-methyl-D-aspartate receptor; Hippocampus
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Funding
- Japan Society for the Promotion of Science (JSPS) [22. 5895]
- Academic Frontier Project from Ministry of Education, Culture, Sports, Science, and Technology of Japan [22. 5895]
- Ministry of Health, Labor, and Welfare
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- NEXT
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Diesel exhaust consists of diesel exhaust particles (DEPs) and gaseous compounds. Previous studies reported that in utero exposure to diesel exhaust affects the central nervous system. However, there was no clear evidence that these effects were caused by diesel exhaust particles themselves, gaseous compounds, or both. Here, we explored the effects of in utero exposure to DEPs on learning and memory in male ICR mice. DEP solutions were administered subcutaneously to pregnant ICR mice at a dose of 0 or 2001.1.g/kg body weight on gestation days 6, 9, 12, 15, and 18. We examined learning and memory in 9-to-10-week-old male offspring using the Morris water maze test and passive avoidance test. Immediately after the behavioral tests, hippocampi were isolated. Hippocampal N-methyl-D-aspartate receptor (NR) expression was also measured by quantitative RT-PCR analysis. Mice exposed to DEPs in utero showed deficits in the Morris water maze test, but their performance was not significantly different from that of control mice in the passive avoidance test. In addition, DEP-exposed mice exhibited decreased hippocampal NR2A expression. The present results indicate that maternal DEP exposure disrupts learning and memory in male offspring, which is associated with reduced hippocampal NR2A expression. (C) 2015 Elsevier Inc. All rights reserved.
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