4.7 Article

Caught in the Act: In Vivo Development of Macrolide Resistance to Campylobacter jejuni Infection

Journal

JOURNAL OF CLINICAL MICROBIOLOGY
Volume 48, Issue 8, Pages 3012-3015

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.00768-10

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Funding

  1. University of Vermont General Clinical Research Center, NIH [MO1 RR000109]
  2. Military Infectious Diseases Research Program
  3. U.S. Naval Research and Development Command Work Unit [6000.RAD1.DA3.A0308]

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We report the first instance of macrolide resistance developing in vivo following appropriate antibiotic use in a healthy volunteer as a part of a controlled human infection with Campylobacter jejuni. In vivo development of macrolide resistance may be an important contributor to antibiotic resistance in C. jejuni.

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