4.7 Article

Computational Analysis Identifies Human Adenovirus Type 55 as a Re-Emergent Acute Respiratory Disease Pathogen

Journal

JOURNAL OF CLINICAL MICROBIOLOGY
Volume 48, Issue 3, Pages 991-993

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.01694-09

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Funding

  1. U.S. Public Health Service NIH [EY013124, P30EY013104]
  2. Massachusetts Lions Eye Research Fund, Inc.
  3. Department of Ophthalmology, Harvard Medical School
  4. Research to Prevent Blindness, Inc.
  5. United States Air Force Surgeon General, Clinical Investigation [FDG20040024E]

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Novel human adenoviruses (HAdVs) arise from genome recombination. Analysis of HAdV type 55 from an outbreak in China shows a hexon recombination between HAdV-B11 and HAdV-B14, resulting in a genome that is 97.4% HAdV-B14. Sporadic appearances as a re-emergent pathogen and misidentification as HAdV-B11a are due to this partial hexon.

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