Related references
Note: Only part of the references are listed.Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: Phase 1 trial outcomes
Eva L. Feldman et al.
ANNALS OF NEUROLOGY (2014)
Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease
Daniel Bilbao et al.
EMBO MOLECULAR MEDICINE (2014)
Experimental trials in amyotrophic lateral sclerosis: a review of recently completed, ongoing and planned trials using existing and novel drugs
Namita A. Goyal et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2014)
Adoptive Transfer of Cytokine-Induced Immunomodulatory Adult Microglia Attenuates Experimental Autoimmune Encephalomyelitis in DBA/1 Mice
Xing-Mei Zhang et al.
GLIA (2014)
Low-Dose Interleukin-2 Therapy: A Driver of an Imbalance between Immune Tolerance and Autoimmunity
Agata Kosmaczewska
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)
Neuroinflammation in Alzheimer's disease: an understanding of physiology and pathology
M. Obulesu et al.
INTERNATIONAL JOURNAL OF NEUROSCIENCE (2014)
Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases
Hugo Gonzalez et al.
JOURNAL OF NEUROIMMUNOLOGY (2014)
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed
Jonathan D. Cherry et al.
JOURNAL OF NEUROINFLAMMATION (2014)
Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?
Hiroshi Mitsumoto et al.
LANCET NEUROLOGY (2014)
State of play in amyotrophic lateral sclerosis genetics
Alan E. Renton et al.
NATURE NEUROSCIENCE (2014)
Reply to Woodruff et al.: C1q and C3-dependent complement pathway activation does not contribute to disease in SOD1 mutant ALS mice
Christian S. Lobsiger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Role for terminal complement activation in amyotrophic lateral sclerosis disease progression
Trent M. Woodruff et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice
Ethan A. Winkler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
IL-4 type 1 receptor signaling up-regulates KCNN4 expression, and increases the KCa3.1 current and its contribution to migration of alternative-activated microglia
Roger Ferreira et al.
Frontiers in Cellular Neuroscience (2014)
NP001 regulation of macrophage activation markers in ALS: A phase I clinical and biomarker study
Robert G. Miller et al.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2014)
Human regulatory T cells against minor histocompatibility antigens: ex vivo expansion for prevention of graft-versus-host disease
Anandharaman Veerapathran et al.
BLOOD (2013)
Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis
Thomas Philips et al.
BRAIN (2013)
T helper-17 activation dominates the immunologic milieu of both amyotrophic lateral sclerosis and progressive multiple sclerosis
Marina Saresella et al.
CLINICAL IMMUNOLOGY (2013)
Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival
Jenny S. Henkel et al.
EMBO MOLECULAR MEDICINE (2013)
Active Demethylation of the Foxp3 Locus Leads to the Generation of Stable Regulatory T Cells within the Thymus
Aras Toker et al.
JOURNAL OF IMMUNOLOGY (2013)
Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis
Weihua Zhao et al.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2013)
GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxicated mice
Lisa M. Kosloski et al.
JOURNAL OF NEUROIMMUNOLOGY (2013)
Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice
Jessica M. Crain et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2013)
An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study (vol 12, pg 435, 2013)
T. M. Miller et al.
LANCET NEUROLOGY (2013)
Therapeutic AAV9-mediated Suppression of Mutant SOD1 Slows Disease Progression and Extends Survival in Models of Inherited ALS
Kevin D. Foust et al.
MOLECULAR THERAPY (2013)
Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis
Hong Nie et al.
NATURE MEDICINE (2013)
Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis
Shin H. Kang et al.
NATURE NEUROSCIENCE (2013)
Amyotrophic lateral sclerosis: a new missense mutation in the SOD1 gene
Rosanna Tortelli et al.
NEUROBIOLOGY OF AGING (2013)
Review: Activation patterns of microglia and their identification in the human brain
D. Boche et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2013)
C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice
Christian S. Lobsiger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
The role of regulatory T cells in neurodegenerative diseases
Feng He et al.
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2013)
A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model
Isaac M. Chiu et al.
CELL REPORTS (2013)
An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study
Timothy M. Miller et al.
LANCET NEUROLOGY (2013)
Alterations of T cell subsets in ALS: a systemic immune activation?
M. Rentzos et al.
ACTA NEUROLOGICA SCANDINAVICA (2012)
Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases
Joshua A. Smith et al.
BRAIN RESEARCH BULLETIN (2012)
Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
Oleg Butovsky et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Youngjin Lee et al.
NATURE (2012)
Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms
Weihua Zhao et al.
NEUROBIOLOGY OF DISEASE (2012)
PERIPHERAL NERVE INFLAMMATION IN ALS MICE: CAUSE OR CONSEQUENCE
Osamu Kano et al.
NEUROLOGY (2012)
Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis
Philippe Corcia et al.
PLOS ONE (2012)
Lumbar Intraspinal Injection of Neural Stem Cells in Patients with Amyotrophic Lateral Sclerosis: Results of a Phase I Trial in 12 Patients
Jonathan D. Glass et al.
STEM CELLS (2012)
Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis
David R. Beers et al.
BRAIN (2011)
Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice
Lijun Wang et al.
HUMAN MOLECULAR GENETICS (2011)
Amyotrophic lateral sclerosis
Matthew C. Kiernan et al.
LANCET (2011)
Emerging targets and treatments in amyotrophic lateral sclerosis
Lorne Zinman et al.
LANCET NEUROLOGY (2011)
Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease
Thomas Philips et al.
LANCET NEUROLOGY (2011)
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
Bahareh Ajami et al.
NATURE NEUROSCIENCE (2011)
Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
Laura Ferraiuolo et al.
NATURE REVIEWS NEUROLOGY (2011)
Review: The role of mitochondria in the pathogenesis of amyotrophic lateral sclerosis
L. M. Duffy et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2011)
Neuroprotective activities of regulatory T cells
Howard E. Gendelman et al.
TRENDS IN MOLECULAR MEDICINE (2011)
Immunosuppressive treatment of patients with amyotrophic lateral sclerosis
L. Werdelin et al.
ACTA NEUROLOGICA SCANDINAVICA (2010)
Interleukin-17 and interleukin-23 are elevated in serum and cerebrospinal fluid of patients with ALS: a reflection of Th17 cells activation?
M. Rentzos et al.
ACTA NEUROLOGICA SCANDINAVICA (2010)
Astrocytes: biology and pathology
Michael V. Sofroniew et al.
ACTA NEUROPATHOLOGICA (2010)
FUS Mutations in Familial Amyotrophic Lateral Sclerosis in the Netherlands
Ewout J. N. Groen et al.
ARCHIVES OF NEUROLOGY (2010)
Extracellular Mutant SOD1 Induces Microglial-Mediated Motoneuron Injury
Weihua Zhao et al.
GLIA (2010)
IL-1β-Mediated Signals Preferentially Drive Conversion of Regulatory T Cells but Not Conventional T Cells into IL-17-Producing Cells
Lequn Li et al.
JOURNAL OF IMMUNOLOGY (2010)
IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients
Milan Fiala et al.
JOURNAL OF NEUROINFLAMMATION (2010)
Microglial Upregulation of Progranulin as a Marker of Motor Neuron Degeneration
Thomas Philips et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2010)
TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia
Ian R. A. Mackenzie et al.
LANCET NEUROLOGY (2010)
Mutant superoxide dismutase 1-induced IL-1β accelerates ALS pathogenesis
Felix Meissner et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?
Stanley H. Appel et al.
TRENDS IN IMMUNOLOGY (2010)
Microglial Physiology: Unique Stimuli, Specialized Responses
Richard M. Ransohoff et al.
ANNUAL REVIEW OF IMMUNOLOGY (2009)
Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis
Shizuo Ohnishi et al.
BRAIN RESEARCH (2009)
First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127-T regulatory cells
Piotr Trzonkowski et al.
CLINICAL IMMUNOLOGY (2009)
Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase
Genevieve Gowing et al.
EXPERIMENTAL NEUROLOGY (2009)
Astrocyte Function and Role in Motor Neuron Disease: A Future Therapeutic Target?
Daniel Blackburn et al.
GLIA (2009)
Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
Hristelina Ilieva et al.
JOURNAL OF CELL BIOLOGY (2009)
Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β
Alessandro Michelucci et al.
JOURNAL OF NEUROIMMUNOLOGY (2009)
Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process
Stefania Mantovani et al.
JOURNAL OF NEUROIMMUNOLOGY (2009)
A systematic review of antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease
Richard W. Orrell et al.
AMYOTROPHIC LATERAL SCLEROSIS (2008)
Design, power, and interpretation of studies in the standard murine model of ALS
Sean Scott et al.
AMYOTROPHIC LATERAL SCLEROSIS (2008)
Cortical excitability testing distinguishes Kennedy's disease from amyotrophic lateral sclerosis
Steve Vucic et al.
CLINICAL NEUROPHYSIOLOGY (2008)
Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration
Angelo C. Lepore et al.
EXPERIMENTAL NEUROLOGY (2008)
Macrophage activation and polarization
Fernando Oneissi Martinez et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2008)
Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
Philip Van Damme et al.
JOURNAL OF CELL BIOLOGY (2008)
The Complement Factor C5a Contributes to Pathology in a Rat Model of Amyotrophic Lateral Sclerosis
Trent M. Woodruff et al.
JOURNAL OF IMMUNOLOGY (2008)
Human anti-inflammatory macrophages induce Foxp3+GITR+CD25+ regulatory T cells, which suppress via membrane-bound TGFβ-1
Nigel D. L. Savage et al.
JOURNAL OF IMMUNOLOGY (2008)
Chondroitin sulfate disaccharide stimulates microglia to adopt a novel regulatory phenotype
Stefanie Ebert et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2008)
Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice
Dick Jaarsma et al.
JOURNAL OF NEUROSCIENCE (2008)
Ablation of Proliferating Microglia Does Not Affect Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Caused by Mutant Superoxide Dismutase
Genevieve Gowing et al.
JOURNAL OF NEUROSCIENCE (2008)
Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas
Y. Komohara et al.
JOURNAL OF PATHOLOGY (2008)
PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
Leanne E. Rivers et al.
NATURE NEUROSCIENCE (2008)
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
Koji Yamanaka et al.
NATURE NEUROSCIENCE (2008)
Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis
S. H. Appel et al.
NEUROLOGY (2008)
NG2 cells generate oligodendrocytes and gray matter astrocytes in the spinal cord
Xiaoqin Zhu et al.
NEURON GLIA BIOLOGY (2008)
Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice
Rebecca Banerjee et al.
PLOS ONE (2008)
Selective assoction of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria
Christine Vande Velde et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice
Koji Yamanaka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
CD4+T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS
David R. Beers et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
Isaac M. Chiu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
NG2 cells generate both oligodendrocytes and gray matter astrocytes
Xiaoqin Zhu et al.
DEVELOPMENT (2008)
CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages
Machteld M. Tiemessen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
Bahareh Ajami et al.
NATURE NEUROSCIENCE (2007)
Microglia: active sensor and versatile effector cells in the normal and pathologic brain
Uwe-Karsten Hanisch et al.
NATURE NEUROSCIENCE (2007)
Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis
Arie Gruzman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
Makiko Nagai et al.
NATURE NEUROSCIENCE (2007)
Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
Francesco Paolo Di Giorgio et al.
NATURE NEUROSCIENCE (2007)
Astrocytes are active players in cerebral innate immunity
Cinthia Farina et al.
TRENDS IN IMMUNOLOGY (2007)
Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia
Weihua Zhao et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Absence of tumor necrosis factor-α does not affect motor neuron disease caused by superoxide dismutase 1 mutations
Genevieve Gowing et al.
JOURNAL OF NEUROSCIENCE (2006)
Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
David R. Beers et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Manuela Neumann et al.
SCIENCE (2006)
ALS:: A disease of motor neurons and their nonneuronal neighbors
Sverine Boillee et al.
NEURON (2006)
Trial of celecoxib in amyotrophic lateral sclerosis
Merit E. Cudkowicz et al.
ANNALS OF NEUROLOGY (2006)
Control of microglial neurotoxicity by the fractalkine receptor
Astrid E. Cardona et al.
NATURE NEUROSCIENCE (2006)
Onset and progression in inherited ALS determined by motor neurons and microglia
Severine Boillee et al.
SCIENCE (2006)
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
E Bettelli et al.
NATURE (2006)
Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis
JN Solomon et al.
GLIA (2006)
The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS
JS Henkel et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2006)
Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice
M Damiano et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Lipopolysaccharide-activated SHP-1-deficient motheaten microglia release increased nitric oxide, TNF-α, and IL-1β
J Zhao et al.
GLIA (2006)
Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
M Urushitani et al.
NATURE NEUROSCIENCE (2006)
Characterization of the caspase cascade in a cell culture model of SOD1-related familial amyotrophic lateral sclerosis: expression, activation and therapeutic effects of inhibition
S Sathasivam et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2005)
Apoptosis in amyotrophic lateral sclerosis - what is the evidence?
S Sathasivam et al.
LANCET NEUROLOGY (2005)
Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model
GS Ralph et al.
NATURE MEDICINE (2005)
Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis
SA Sargsyan et al.
GLIA (2005)
Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
V Viglietta et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis:: an [11C](R)-PK11195 positron emission tomography study
MR Turner et al.
NEUROBIOLOGY OF DISEASE (2004)
Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue
JS Henkel et al.
ANNALS OF NEUROLOGY (2004)
Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man
LR Fischer et al.
EXPERIMENTAL NEUROLOGY (2004)
Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria
J Liu et al.
NEURON (2004)
Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells
MC Graves et al.
AMYOTROPHIC LATERAL SCLEROSIS (2004)
Increased cytotoxic potential of microglia from ALS-transgenic mice
P Weydt et al.
GLIA (2004)
Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice
AM Clement et al.
SCIENCE (2003)
Protein aggregation in motor neurone disorders
JD Wood et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2003)
Cutting edge:: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis
AP Kohm et al.
JOURNAL OF IMMUNOLOGY (2002)
Inflammatory processes in amyotrophic lateral sclerosis
PL McGeer et al.
MUSCLE & NERVE (2002)
Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients
FR Wiedemann et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Induction of pro inflammatory molecules in mice with amyotrophic lateral sclerosis:: No requirement for proapoptotic interleukin-1β in neurodegeneration
MD Nguyen et al.
ANNALS OF NEUROLOGY (2001)
Immune reactivity in a mouse model of familial ALS correlates with disease progression
ME Alexianu et al.
NEUROLOGY (2001)
Survival in a transgenic model of FALS is independent of iNOS expression
M Son et al.
ANNALS OF NEUROLOGY (2001)
Glutamate slows axonal transport of neurofilaments in transfected neurons
S Ackerley et al.
JOURNAL OF CELL BIOLOGY (2000)
Share Paper
