Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 46, Issue 7, Pages 2175-2183Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.00065-08
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Funding
- National Institutes of Health [R21 AI063147]
- National Institutes of Health Fogarty International Center [D43 TW00018, U2R TW006885]
- Laura Cook Hull Trust
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
- Fogarty International Center
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Capes)
- Ministry of Education, Brazil
- LCHTF
- National Institutes of Health, NIAID
- [U2R TW006901]
- [110.288/2007]
- [T32 AI 07613]
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Molecular genotyping has shown Mycobacterium tuberculosis lineages to be geographically restricted and associated with distinct ethnic populations. Whether tuberculosis (TB) caused by some M. tuberculosis lineages can present with a differential clinical spectrum is controversial because of very limited clinical data. We recently reported on the discovery of RDRio M. tuberculosis, a Latin American-Mediterranean sublineage that is the predominant cause of TB in Rio de Janeiro, Brazil. To investigate the clinical attributes of TB caused by RDRio strains, we studied a cohort of TB cases from Belo Horizonte, Brazil, in which clinical information recorded on a standardized questionnaire was collected at the time of microbiological testing. These patients were referred for culture and drug susceptibility testing because of the clinical suspicion of complicated TB, as demonstrated by high rates of multidrug resistance (12%) and cavitary TB (80%). We performed spoligo-typing and RDRio genotyping on the M. tuberculosis strains and analyzed the clinical data from these patients. RDRio M. tuberculosis accounted for 37% of the total TB burden. Multivariate analysis found a significant association between TB caused by RDRio strains and pulmonary cavitation and residence in Belo Horizonte. Since cavitary TB is associated with higher sputum bacillary load, our findings support the hypothesis that RDRio M. tuberculosis is associated with a more severe disease as a strategy to increase transmission. Future studies are needed to confirm these observations and to better define the contribution of RDRio M. tuberculosis to the global TB epidemic.
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