4.7 Article

Presence of the KPC Carbapenemase Gene in Enterobacteriaceae Causing Bacteremia and Its Correlation with In Vitro Carbapenem Susceptibility

Journal

JOURNAL OF CLINICAL MICROBIOLOGY
Volume 47, Issue 1, Pages 239-241

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.02123-08

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Funding

  1. Swiss National Science Foundation [PBBSB-113014]
  2. NIH [K23 AI050585, IK24 AI 06779401]
  3. CDC [CDC 1U1CI000033301]
  4. Sage Products Inc.
  5. NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [K23AI050585] Funding Source: NIH RePORTER

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During 6 months, we obtained Enterobacteriaceae isolates from patients with gram-negative bacteremia at a 1,250-bed teaching hospital in St. Louis, MO, and compared carbapenem susceptibilities with the presence of (KPC)-K-bla, a transferable carbapenemase gene. Three (1.2%) out of 243 isolates were (KPC)-K-bla positive. Ertapenem nonsusceptibility had a low positive predictive value.

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