Journal
JOURNAL OF CLINICAL LIPIDOLOGY
Volume 5, Issue 5, Pages 373-379Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacl.2011.06.007
Keywords
Blood-brain barrier; Brain cholesterol; 24S-Hydroxycholesterol; Lathosterol; Statins
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Funding
- [MZO 00179906]
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BACKGROUND: Growing evidence suggests that different statins are able to lower brain cholesterol synthesis. It is not clear yet whether lipophilic statins influence brain cholesterol in different way than hydrophilic ones. SOURCES OF MATERIAL: The MEDLINE database. FINDINGS: According to the data reported thus far, statins may influence brain cholesterol metabolism directly (because they are able to penetrate BBB no matter whether they are hydrophilic or lipophilic) and also indirectly (by lowering plasma cholesterol). Although the definite mechanism is not known yet, it becomes obvious that statins do not only influence peripheral but also central cholesterol pool. CONCLUSION: Better understanding of the effects of statins on brain metabolism becomes more important because many studies bring evidence of a possible link between cholesterol and neurodegeneration. (C) 2011 National Lipid Association. All rights reserved.
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