Journal
JOURNAL OF CLINICAL LIPIDOLOGY
Volume 2, Issue 2, Pages S29-S33Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacl.2008.01.009
Keywords
Bile acids; Bile acid sequestrants; Colesevelam; Glucose control
Categories
Funding
- Merck/Schering-Plough
- Daiichi Sankyo, Inc.
- Unilever, Inc.
Ask authors/readers for more resources
The digestive tract plays a key role in lipid metabolism and in cardiovascular risk through the physiology of bile acids on lipid absorption, enterohepatic recycling of bile acids. and cholesterol oxidation in synthesis of bile acids. Recent evidence associates the activation of farnesoid X receptor by bile acids with alterations in high-density lipoprotein cholesterol, triglyceride metabolism. and glucose metabolism. Bile-acid sequestrants augment cholesterol excretion via enhanced conversion to bile acids to lower low-density lipoprotein cholesterol. Several recent studies have demonstrated a role for the bile-acid sequestrant colesevelam hydrochloride in improving glycemic control as well as lipid profiles in subjects with type 2 diabetes. This work reviews the mechanisms of action of colesevelam hydrochloride in interrupting bile acid reabsorption and in lipid transport and glucose control. (C) 2008 National Lipid Association. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available