Journal
JOURNAL OF CLINICAL LIPIDOLOGY
Volume 2, Issue 4, Pages 298-303Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacl.2008.06.004
Keywords
Cardiovascular disease; Cohort study; Coronary heart disease; F2-isoprostanes; Mass spectrometry; Prostaglandin; Stroke
Categories
Ask authors/readers for more resources
BACKGROUND: F2-isoprostanes are prostaglandin-like compounds formed via arachidonic acid oxidation during oxidative stress. OBJECTIVE: To study the relation between urinary concentrations of 8-iso-prostaglandin F2 alpha (8-iso PGF2 alpha) and mortality due to cardiovascular disease (CVD) in a nested case-cohort design. METHODS: Follow-up duration of this prospective Study among postmenopausal women was 18 years. Cases included 141 women who died of coronary heart disease and 109 women who died of stroke, whereas controls were a random cohort sample of 142 women. The concentration of 8-iso PGF2 alpha was determined with liquid chromatography/tandem mass spectrometry in urine samples collected at baseline. RESULTS: Smokers had 34.8% higher urinary 8-iso PGF2 alpha concentrations than nonsmokers (P < 0.0011). High levels Of urinary 8-iso PGF2 alpha were associated with increased incidence of fatal CVD. Women who were in the highest quartile of urinary 8-iso PGF2 alpha levels had, independently of age, an odds ratio of 1.8 (95% confidence interval, 1.1-3.1, P < 0.05) for CVD mortality. Further adjustment by systolic blood pressure, history of CVD, diabetes, smoking, and body mass index did not attenuate this association. CONCLUSION: Women with high levels Of Urinary 8-iso PGF2 alpha had an 80% increased risk of dying of coronary heart disease or stroke, supporting involvement of oxidative stress in the pathophysiology of cardiovascular disease. (C) 2008 National Lipid Association. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available