Journal
JOURNAL OF CLINICAL LABORATORY ANALYSIS
Volume 23, Issue 3, Pages 175-178Publisher
WILEY
DOI: 10.1002/jcla.20315
Keywords
soluble type I IL-1 receptor (sIL-1RI); human; ELISA
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The levels of several soluble cytokine receptors in body fluids of healthy individuals change with age. Clinical application of the measurement of the serum soluble interleukin-1 receptor type I (sIL-1 RI) level depends critically on the samples used as the controls. At present, there is no information regarding the levels of serum sIL-1 RI in healthy subjects. The purpose of this study is to reveal the age-related changes that occur in the serum sIL-1RI levels of healthy individuals. We determined the serum sIL-1RI levels of healthy Japanese children using ELISA. The serum sIL-1RI level of children (0-14 years) was significantly higher than that of adults (more than 15 years) (P = 0.0138, n = 90). Thus, it is recommended that when the serum sIL-1RI level of patients is evaluated, it should be compared against age-matched controls. J. Clin. Lab. Anal. 23:175-178, 2009. (C) 2009 Wiley-Liss, Inc.
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