Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 128, Issue 9, Pages 3662-3670Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI120842
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Funding
- Leducq Foundation
- Progeria Research Foundation
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The biological basis of human aging remains one of the greatest unanswered scientific questions. Increasing evidence, however, points to a role for alterations in mitochondrial function as a potential central regulator of the aging process. Here, we focus primarily on three aspects of mitochondrial biology that link this ancient organelle to how and why we age. In particular, we discuss the role of mitochondria in regulating the innate immune system, the mechanisms linking mitochondrial quality control to age-dependent pathology, and the possibility that mitochondrial-to-nuclear signaling might regulate the rate of aging.
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