Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 124, Issue 6, Pages 2355-2363Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI72269
Keywords
-
Categories
Funding
- NIH [DK088934, 091623, 079312]
- Veterans Administration through Merit Review Award
Ask authors/readers for more resources
Acute kidney injury (AKI) remains a major clinical event with rising incidence, severity, and cost; it now has a morbidity and mortality exceeding acute myocardial infarction. There is also a documented conversion to and acceleration of chronic kidney disease to end-stage renal disease. The multifactorial nature of AKI etiologies and pathophysiology and the lack of diagnostic techniques have hindered translation of preclinical success. An evolving understanding of epithelial, endothelial, and inflammatory cell interactions and individualization of care will result in the eventual development of effective therapeutic strategies. This review focuses on epithelial and endothelial injury mediators, interactions, and targets for therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available