Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 124, Issue 6, Pages 2365-2368Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI75803
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Funding
- NHLBI NIH HHS [R01 HL056416, R01 HL112669, R01 HL067384, R01 HL67384] Funding Source: Medline
- NIDDK NIH HHS [U54 DK106846, P30 DK090948, P01 DK090948] Funding Source: Medline
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In this issue of the JCI, Chaurasia and colleagues report an impressive ex vivo expansion of HSCs from human cord blood (CB) using cytokines and altering epigenetic modifications. The application of this protocol provides information that has potential for clinical consideration. The enhanced expansion of CB HSCs is a substantial advance over recent work from the Chaurasia and Hoffman group, in which ex vivo production of human erythroid progenitor cells from CB was promoted by chromatin modification. Moreover, this study takes advantage of information from the rapidly emerging, but not yet fully elucidated, field of epigenetics.
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