Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 123, Issue 5, Pages 1911-1918Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI66024
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Funding
- Ministry of Education, Culture, Sports, Science and Technology
- National Cancer Center Research and Development Fund of Japan
- Intramural Research Program of the Center for Cancer Research, US National Cancer Institute [Z01 BC010876]
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Liver cancer is an aggressive disease with a poor outcome. Several hepatic stem/progenitor markers are useful for isolating a subset of liver cells with stem cell features, known as cancer stem cells (CSCs). These cells are responsible for tumor relapse, metastasis, and chemoresistance. Liver CSCs dictate a hierarchical organization that is shared in both organogenesis and tumorigenesis. An increased understanding of the molecular signaling events that regulate cellular hierarchy and sternness, and success in defining key CSC-specific genes, have opened up new avenues to accelerate the development of novel diagnostic and treatment strategies. This Review highlights recent advances in understanding the pathogenesis of liver CSCs and discusses unanswered questions about the concept of liver CSCs.
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