Antiinflammatory effects of apoptotic cells

Apoptotic cells are rapidly phagocytosed by macrophages, a process that represents a critical step in tissue remodeling, immune responses, and the resolution of inflammation. In 1998, Peter Henson, Donna Bratton, and colleagues at National Jewish Health demonstrated that phagocytosis of apoptoric cells actively suppresses inflammation by inhibiting the production of inflammatory cytokines and inducing production of antiinflammatory factors, including TGF-beta and prostaglandin E2. Here they discuss the evolving relationship among apoptosis, phagocytosis, and inflammation.