Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 123, Issue 3, Pages 973-979Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI64094
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Funding
- American Heart Association predoctoral fellowship
- NIH National Research Service Award Kirschstein fellowship
- Ewha Womans University
- Dana-Farber Cancer Institute
- American Diabetes Association
- Department of Defense
- NIH/NIDDK [RO1069966]
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The 7 mammalian sirtuin proteins compose a protective cavalry of enzymes that can be invoked by cells to aid in the defense against a vast array of stressors. The pathologies associated with aging, such as metabolic syndrome, neurodegeneration, and cancer, are either caused by or exacerbated by a lifetime of chronic stress. As such, the activation of sirtuin proteins could provide a therapeutic approach to buffer against chronic stress and ameliorate age-related decline. Here we review experimental evidence both for and against this proposal, as well as the implications that isoform-specific sirtuin activation may have for healthy aging in humans.
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