Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 123, Issue 9, Pages 3678-3684Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI69600
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Funding
- NIH [5T32GM007062-38, 1R01CA157996-02]
- Children's Cancer Fund
- Damon-Runyon Cancer Research Foundation
- Welch Foundation [I-1733]
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Glutamine is an abundant and versatile nutrient that participates in energy formation, redox homeostasis, macromolecular synthesis, and signaling in cancer cells. These characteristics make glutamine metabolism an appealing target for new clinical strategies to detect, monitor, and treat cancer. Here we review the metabolic functions of glutamine as a super nutrient and the surprising roles of glutamine in supporting the biological hallmarks of malignancy. We also review recent efforts in imaging and therapeutics to exploit tumor cell glutamine dependence, discuss some of the challenges in this arena, and suggest a disease-focused paradigm to deploy these emerging approaches.
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