Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 123, Issue 10, Pages 4121-4130Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI67714
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Funding
- NIH [RO1DK60590, RO1DK071560, U19 AI1066328, R21AI103361, R56AI100991, K24AI083742, R01HD075549]
- VA Merit Review grants
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Since the discovery of hepatitis C virus (HCV) by molecular cloning almost a quarter of a century ago, unprecedented at the time because the virus had never been grown in cell culture or detected serologically, there have been impressive strides in many facets of our understanding of the natural history of the disease, the viral life cycle, the pathogenesis, and antiviral therapy. It is apparent that the virus has developed multiple strategies to evade immune surveillance and eradication. This Review covers what we currently understand of the temporal and spatial immunological changes within the human innate and adaptive host immune responses that ultimately determine the outcomes of HCV infection.
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