Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 123, Issue 3, Pages 996-1002Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI66370
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Funding
- NIH [R21 HL104345, RO1 CA160433]
- Maryland Stem Cell and Commonwealth Foundations
- Flight Attendants Medical Research Institute
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Telomere length shortens with age and predicts the onset of replicative senescence. Recently, short telomeres have been linked to the etiology of degenerative diseases such as idiopathic pulmonary fibrosis, bone marrow failure, and cryptogenic liver cirrhosis. These disorders have recognizable clinical manifestations, and the telomere defect explains their genetics and informs the approach to their treatment. Here, I review how telomere biology has become intimately connected to clinical paradigms both for understanding pathophysiology and for individualizing therapy decisions. I also critically examine nuances of interpreting telomere length measurement in clinical studies.
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