Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 123, Issue 4, Pages 1419-1422Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI69071
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Funding
- NIAMS NIH HHS [R01-AR052672, R37 AR043380, R01 AR052672] Funding Source: Medline
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Desmoglein-1 (DSG1), a desmosomal protein, maintains the structure of epidermis through its adhesive function. However, heterozygous mutations in DSG1 in humans result in abnormal differentiation, as does downregulation of DSG1 in human skin organ culture, suggesting that it may have important signaling functions. In this issue of the JCI, Harmon et al. elucidate how the binding of the DSG1 cytoplasmic tail to the scaffolding protein Erbin decreases signaling through the Ras-Raf pathway to promote stratification and differentiation of keratinocytes in the epidermis.
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