Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 122, Issue 11, Pages 3824-3834Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI64124
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Funding
- Canadian Paraplegic Association (Ontario branch)
- Christopher and Dana Reeve Foundation
- Physicians' Services Incorporated
- Ontario Neurotrauma Foundation
- Krembil Foundation SCI-NET
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Spinal cord injury (SCI) is a devastating condition producing great personal and societal costs and for which there is no effective treatment. Stem cell transplantation is a promising therapeutic strategy, though much preclinical and clinical research work remains. Here, we briefly describe SCI epidemiology, pathophysiology, and experimental and clinical stem cell strategies. Research in stem cell biology and cell reprogramming is rapidly advancing, with the hope of moving stem cell therapy closer to helping people with SCI. We examine issues important for clinical translation and provide a commentary on recent developments, including termination of the first human embryonic stem cell transplantation trial in human SCI.
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