Related references
Note: Only part of the references are listed.Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia
Nicolas Goardon et al.
CANCER CELL (2011)
AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias
Stephen M. Sykes et al.
CELL (2011)
Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
Yonghao Yu et al.
SCIENCE (2011)
The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
Peggy P. Hsu et al.
SCIENCE (2011)
Inhibition of MEK/ERK signaling induces apoptosis of acute myelogenous leukemia cells via inhibition of eukaryotic initiation factor 4E-binding protein 1 and down-regulation of Mcl-1
Chie Nishioka et al.
APOPTOSIS (2010)
4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors
Qing-Bai She et al.
CANCER CELL (2010)
mTOR Activation Induces Tumor Suppressors that Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells after Pten Deletion
Jae Y. Lee et al.
CELL STEM CELL (2010)
The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML
Yingzi Wang et al.
SCIENCE (2010)
Autophagy and Metabolism
Joshua D. Rabinowitz et al.
SCIENCE (2010)
mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs
Ryan J. O. Dowling et al.
SCIENCE (2010)
Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells
Tim C. P. Somervaille et al.
CELL STEM CELL (2009)
Nutrient-dependent mTORC1 Association with the ULK1-Atg13-FIP200 Complex Required for Autophagy
Nao Hosokawa et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
Molecular mechanisms of mTOR-mediated translational control
Xiaoju Max Ma et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Direct control of mitochondrial function by mTOR
Arvind Ramanathan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
New Insights into mTOR Signaling: mTORC2 and Beyond
Dario R. Alessi et al.
SCIENCE SIGNALING (2009)
Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
Pazit Polak et al.
CELL METABOLISM (2008)
Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
C. Florian Bentzinger et al.
CELL METABOLISM (2008)
A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies
David A. Rizzieri et al.
CLINICAL CANCER RESEARCH (2008)
Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events
Caterina Nardella et al.
GENES & DEVELOPMENT (2008)
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
Chong Chen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization
Boyi Gan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
Andrew Y. Choo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
John T. Cunningham et al.
NATURE (2007)
RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation
Philippe P. Roux et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells
Margaret E. M. Van Meter et al.
BLOOD (2007)
PRAS40 deregulates apoptosis in malignant melanoma
SubbaRao V. Madhunapantula et al.
CANCER RESEARCH (2007)
Restoration of p53 function leads to tumour regression in vivo
Andrea Ventura et al.
NATURE (2007)
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα but not S6K1
David A. Guertin et al.
DEVELOPMENTAL CELL (2006)
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
Estela Jacinto et al.
CELL (2006)
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
Tim C. P. Somervaille et al.
CANCER CELL (2006)
Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications
Ingo Roeder et al.
NATURE MEDICINE (2006)
Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
Karen W. L. Yee et al.
CLINICAL CANCER RESEARCH (2006)
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
Andrei V. Krivtsov et al.
NATURE (2006)
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
Omer H. Yilmaz et al.
NATURE (2006)
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
Jiwang Zhang et al.
NATURE (2006)
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
DD Sarbassov et al.
MOLECULAR CELL (2006)
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
KE O'Reilly et al.
CANCER RESEARCH (2006)
Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
SY Sun et al.
CANCER RESEARCH (2005)
Dynamics of chronic myeloid leukaemia
F Michor et al.
NATURE (2005)
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins
XM Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Antileukemic activity of rapamycin in acute myeloid leukemia
C Récher et al.
BLOOD (2005)
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
BJP Huntly et al.
CANCER CELL (2004)
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
DC Fingar et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
A Cozzio et al.
GENES & DEVELOPMENT (2003)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim et al.
CELL (2002)
Stem cells, cancer, and cancer stem cells
T Reya et al.
NATURE (2001)
Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase
XM Wang et al.
EMBO JOURNAL (2001)
Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice
C Lavau et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Plat-E: an efficient and stable system for transient packaging of retroviruses
S Morita et al.
GENE THERAPY (2000)