Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 122, Issue 11, Pages 3817-3823Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI61974
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Funding
- NIH [DK083556, EB009237, DC009655]
- American Society of Transplantation
- Excellence in Academic Medicine Act through the Illinois Department of Healthcare and Family Services
- Northwestern Memorial Foundation Dixon Translational Research Grants Initiative
- Zell Family Foundation
- American Association for the Study of Liver Diseases
- American Liver Foundation Liver Scholar Award
- Health Resources and Services Administration [234-2005-37011C]
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There is an ever-growing demand for transplantable organs to replace acute and chronically damaged tissues. This demand cannot be met by the currently available donor organs. Efforts to provide an alternative source have led to the development of organ engineering, a discipline that combines cell biology, tissue engineering, and cell/organ transplantation. Over the last several years, engineered organs have been implanted into rodent recipients and have shown modest function. In this article, we summarize the most recent advances in this field and provide a perspective on the challenges of translating this promising new technology into a proven regenerative therapy.
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