Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 121, Issue 10, Pages 3810-3818Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI57088
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Funding
- Norwegian Cancer Association
- Radiumhospitalets legater
- Norwegian Research Council
- Raagholdt Foundation
- Torsteds legat
- Alice Kleberg Reynolds Foundation
- Department of the Army [W81XWH04-1-0477]
- Breast Cancer Research Foundation
- Norwegian Research Council [155218/V40, 175240/S10]
- Norwegian Cancer Society [D99061]
- Health Region South East
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Rapid and sophisticated improvements in molecular analysis have allowed us to sequence whole human genomes as well as cancer genomes, and the findings suggest that we may be approaching the ability to individualize the diagnosis and treatment of cancer. This paradigmatic shift in approach will require clinicians and researchers to overcome several challenges including the huge spectrum of tumor types within a given cancer, as well as the cell-to-cell variations observed within tumors. This review discusses how next-generation sequencing of breast cancer genomes already reveals insight into tumor heterogeneity and how it can contribute to future breast cancer classification and management.
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