Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 121, Issue 6, Pages 2094-2101Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI45887
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Funding
- NIH [R01-DK55758, R01-CA112023, RC1-DK086629, P01-DK088761]
- Juvenile Diabetes Foundation [JDRF 3-2008-130]
- Merck Co.
- Life Sciences Institute of the University of Michigan
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To fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed state. As such, the tissue requires potent mechanisms to remodel, acutely and chronically. Adipocytes can rapidly reach the diffusional limit of oxygen during growth; hypoxia is therefore an early determinant that limits healthy expansion. Proper expansion requires a highly coordinated response among many different cell types, including endothelial precursor cells, immune cells, and preadipocytes. There are therefore remarkable similarities between adipose expansion and growth of solid tumors, a phenomenon that presents both an opportunity and a challenge, since pharmacological interventions supporting healthy adipose tissue adaptation can also facilitate tumor growth.
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