Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 121, Issue 6, Pages 2102-2110Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI46069
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Funding
- American Diabetes Association [7-08-RA-57, 7-07-JF-43]
- USDA Agricultural Research Service [58-1950-7-707]
- Department of Veterans Affairs Office of Research and Development Medical Research Service
- NIH [AG028098, DK0822574, 1RC2ES018781, R24DK087669, DK56598, DK59935, RO1-HD045962, PO1-HD38129, 3P30DK046200, DK074979, DK085008]
- Merck Co.
- Life Sciences Institute of the University of Michigan
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Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.
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