4.8 Article

MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1L613V mutation

Related references

Note: Only part of the references are listed.
Article Medicine, Research & Experimental

Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation

Talita M. Marin et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Genetics & Heredity

The Face of Noonan Syndrome: Does Phenotype Predict Genotype

Judith E. Allanson et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2010)

Article Medicine, Research & Experimental

Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload

Norifumi Takeda et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Medicine, Research & Experimental

Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome-associated Sos1 mutation

Peng-Chieh Chen et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Genetics & Heredity

A restricted spectrum of NRAS mutations causes Noonan syndrome

Ion C. Cirstea et al.

NATURE GENETICS (2010)

Review Pharmacology & Pharmacy

Molecular targets and regulators of cardiac hypertrophy

Rohini Agrawal et al.

PHARMACOLOGICAL RESEARCH (2010)

Article Genetics & Heredity

Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back

Katherine A. Rauen et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2009)

Article Cardiac & Cardiovascular Systems

Cardiomyocyte-Specific Loss of Neurofibromin Promotes Cardiac Hypertrophy and Dysfunction

Junwang Xu et al.

CIRCULATION RESEARCH (2009)

Review Cell Biology

The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation

William E. Tidyman et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2009)

Article Endocrinology & Metabolism

Malignant Diseases in Noonan Syndrome and Related Disorders

Henrik Hasle

HORMONE RESEARCH (2009)

Article Biochemistry & Molecular Biology

Cardiac hypertrophy: Targeting Raf/MEK/ERK1/2-signaling

Kristina Lorenz et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)

Review Pathology

Hypertrophic cardiomyopathy: current understanding and treatment objectives

G. S. Soor et al.

JOURNAL OF CLINICAL PATHOLOGY (2009)

Article Multidisciplinary Sciences

Endogenous expression of HrasG12V induces developmental defects and neoplasms with copy number imbalances of the oncogene

Xu Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Noonan syndrome is associated with enhanced pERK activity, the repression of which can prevent craniofacial malformations

Tomoki Nakamura et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation

Toshiyuki Araki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Chemistry, Medicinal

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

Stephen D. Barrett et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)

Review Oncology

The tyrosine phosphatase Shp2 (PTPN11) in cancer

Gordon Chan et al.

CANCER AND METASTASIS REVIEWS (2008)

Review Genetics & Heredity

The RAS/MAPK syndromes: Novel roles of the RAS pathway in human genetic disorders

Yoko Aoki et al.

HUMAN MUTATION (2008)

Article Multidisciplinary Sciences

Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome

Maike Krenz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo

Nicole H. Purcell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Genetics & Heredity

Germline gain-of-function mutations in RAF1 cause Noonan syndrome

M. Abdur Razzaque et al.

NATURE GENETICS (2007)

Article Medicine, Research & Experimental

Mediating ERK1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome

Tomoki Nakamura et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Review Biochemistry & Molecular Biology

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

James A. McCubrey et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)

Article Genetics & Heredity

Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations

Martin Zenker et al.

JOURNAL OF MEDICAL GENETICS (2007)

Article Genetics & Heredity

Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome

Marco Tartaglia et al.

NATURE GENETICS (2007)

Article Genetics & Heredity

Germline gain-of-function mutations in SOS1 cause Noonan syndrome

Amy E. Roberts et al.

NATURE GENETICS (2007)

Review Cell Biology

Regulation of cardiac hypertrophy by intracellular signalling pathways

Joerg Heineke et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: Consequences for PI3K binding on Gab1

Nadine Hanna et al.

FEBS LETTERS (2006)

Article Cardiac & Cardiovascular Systems

Electrotonic modulation of cardiac impulse conduction by myofibroblasts

M Miragoli et al.

CIRCULATION RESEARCH (2006)

Article Biochemistry & Molecular Biology

PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects

MI Kontaridis et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Multidisciplinary Sciences

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

P Rodriguez-Viciana et al.

SCIENCE (2006)

Article Genetics & Heredity

Germline KRAS mutations cause Noonan syndrome

S Schubbert et al.

NATURE GENETICS (2006)

Article Genetics & Heredity

Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

T Niihori et al.

NATURE GENETICS (2006)

Article Genetics & Heredity

Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease

M Tartaglia et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2006)

Article Genetics & Heredity

HRAS mutation analysis in Costello syndrome: Genotype and phenotype correlation

KW Gripp et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2006)

Article Genetics & Heredity

Germline mutations in HRAS proto-oncogene cause Costello syndrome

Y Aoki et al.

NATURE GENETICS (2005)

Review Cardiac & Cardiovascular Systems

Does load-induced ventricular hypertrophy progress to systolic heart failure?

K Berenji et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2005)

Article Cardiac & Cardiovascular Systems

Adenosine monophosphate-activated protein kinase disease mimicks hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome - Natural history

RT Murphy et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2005)

Article Biochemistry & Molecular Biology

Shp2 regulates Src family kinase activity and Ras/Erk activation by controlling Csk recruitment

SQ Zhang et al.

MOLECULAR CELL (2004)

Article Multidisciplinary Sciences

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

EE Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Cardiac & Cardiovascular Systems

Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart

MZ Zheng et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)

Article Genetics & Heredity

Clinical variability in a Noonan syndrome family with a new PTPN11 gene mutation

DR Bertola et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2004)

Article Cardiac & Cardiovascular Systems

Mutation analysis of AMP-activated protein kinase subunits in inherited cardiomyopathies: implications for kinase function and disease pathogenesis

SMJ Oliveira et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2003)

Review Cardiac & Cardiovascular Systems

Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death

OF Bueno et al.

CIRCULATION RESEARCH (2002)

Review Endocrinology & Metabolism

Leptin: a review of its peripheral actions and interactions

S Margetic et al.

INTERNATIONAL JOURNAL OF OBESITY (2002)

Article Cardiac & Cardiovascular Systems

Prevention of hypertrophy by overexpression of Kv4.2 in cultured neonatal cardiomyocytes

C Zobel et al.

CIRCULATION (2002)

Review Medicine, General & Internal

Hypertrophic cardiomyopathy - A systematic review

BJ Maron

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2002)

Article Biochemistry & Molecular Biology

Divergent roles of SHP-2 in ERK activation by leptin receptors

C Bjorbæk et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Cardiac & Cardiovascular Systems

The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo

OF Bueno et al.

CIRCULATION RESEARCH (2001)

Article Biochemistry & Molecular Biology

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

OF Bueno et al.

EMBO JOURNAL (2000)