Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 121, Issue 1, Pages 238-248Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI42520
Keywords
-
Categories
Funding
- National Institute of Allergy and Infectious Diseases (NIAID), NIH
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI001080] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Biofilms are surface-attached agglomerations of microorganisms embedded in an extracellular matrix Biofilm-associated infections are difficult to eradicate and represent a significant reservoir for disseminating and recurring serious infections Infections involving biofilms frequently develop on indwelling medical devices in hospitalized patients, and Staphylococcus epidermidis is the leading cause of infection in this setting However, the molecular determinants of biofilm dissemination are unknown Here we have demonstrated that specific secreted, surfactant-like S epidermidis peptides - the beta subclass of phenol-soluble modulins (PSMs) - promote S epidermidis biofilm structuring and detachment in vitro and dissemination from colonized catheters in a mouse model of device-related infection Our study establishes in vivo significance of biofilm detachment mechanisms for the systemic spread of biofilm-associated infection and identifies the effectors of biofilm maturation and detachment in a premier biofilm-forming pathogen Furthermore, by demonstrating that antibodies against PSM beta peptides inhibited bacterial spread from indwelling medical devices, we have provided proof of principle that interfering with biofilm detachment mechanisms may prevent dissemination of biofilm-associated infection
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available