Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 121, Issue 1, Pages 6-13Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI44947
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Funding
- NIAID [R01AI046954, U01AI070469, U19AI083025, U54AI057158, P01AI058113, 1F32AI081428]
- CRIP an NIAID funded Center of Excellence for Influenza Research and Surveillance [HHSN266200700010C]
- W M Keck Foundation
- Vivaldi BioScience
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P01AI058113, U01AI070469, U54AI057158, F32AI081428, U19AI083025, R01AI046954] Funding Source: NIH RePORTER
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Influenza A viruses cause recurrent, seasonal epidemics and occasional global pandemics with devastating levels of morbidity and mortality The ability of influenza A viruses to adapt to various hosts and undergo reassortment events ensures constant generation of new strains with unpredictable degrees of pathogenicity, transmissibility, and pandemic potential Currently, the combination of factors that drives the emergence of pandemic influenza is unclear, making it impossible to foresee the details of a future outbreak Identification and characterization of influenza A virus virulence determinants may provide insight into genotypic signatures of pathogenicity as well as a more thorough understanding of the factors that give rise to pandemics
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