Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 121, Issue 10, Pages 3804-3809Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI57099
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Funding
- Dompe
- NIH [CA129765, CA101860]
- American Association for Cancer Research (SU2C Dream Team Award)
- Breast Cancer Research Foundation
- Taubman Research Institute
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Many tumors, including breast cancer, are maintained by a subpopulation of cells that display stem cell properties, mediate metastasis, and contribute to treatment resistance. These cancer stem cells (CSCs) are regulated by complex interactions with the components of the tumor microenvironment - including mesenchymal stem cells, adipocytes, tumor associated fibroblasts, endothelial cells, and immune cells - through networks of cytokines and growth factors. Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development.
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