Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 121, Issue 7, Pages 2534-2542Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI46262
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Funding
- Merck and Co. Inc.
- Burroughs Wellcome Fund
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [K08AR054859]
- NIH [HD055601, K99AR055668]
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Over the past decade and a half, the biomedical community has uncovered a previously unappreciated reciprocal relationship between cells of the immune and skeletal systems. Work in this field, which has been termed osteoimmunology, has resulted in the development of clinical therapeutics for seemingly disparate diseases linked by the common themes of inflammation and bone remodeling. Here, the important concepts and discoveries in osteoimmunology are discussed in the context of the diseases bridging these two organ systems, including arthritis, osteoporosis, cancer, and infection, and the targeted treatments used by clinicians to combat them.
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