Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 120, Issue 10, Pages 3421-3431Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI42918
Keywords
-
Categories
Funding
- US NIH [DK073495]
- American Society of Nephrology
- Deutsche Forschungsgemeinschaft [SFB 850]
- Centre of Chronic Immunodeficiency [TP8]
- Excellence Initiative of the German Federal and State Governments [EXC 294]
- European Union [201279]
Ask authors/readers for more resources
Cathepsins were originally identified as proteases that act in the lysosome. Recent work has uncovered nontraditional roles for cathepsins in the extracellular space as well as in the cytosol and nucleus. There is strong evidence that subspecialized and compartmentalized cathepsins participate in many physiologic and pathophysiologic cellular processes, in which they can act as both digestive and regulatory proteases. In this review, we discuss the transcriptional and translational control of cathepsin expression, the regulation of intracellular sorting of cathepsins, and the structural basis of cathepsin activation and inhibition. In particular, we highlight the emerging roles of various cathepsin forms in disease, particularly those of the cardiac and renal systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available