Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 120, Issue 1, Pages 20-28Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI40820
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The ability to create new functional cardiomyocytes is the holy grail of cardiac regenerative medicine. From studies using model organisms, new insights into the fundamental pathways that drive heart muscle regeneration have begun to arise as well as a growing knowledge of the distinct families of multipotent cardiovascular progenitors that generate diverse lineages during heart development. In this Review, we highlight this intersection of the pregenerative biology of heart progenitor cells and heart regeneration and discuss the longer term challenges and opportunities in moving toward a therapeutic goal of regenerative cardiovascular medicine.
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